I-SLU‑PP‑332 4‑I-Hydroxy‑N'‑(2‑naphthylmethylene)benzohydrazide CAS 303760‑60‑3
SLU‑PP-332 CAS 303760‑60‑3yi-compound yophando lwe-agonist enxulumene ne-pan-estrogen (ERR) enamandla, i-white-off-white fine powder. Ibonisa ukuhambelana okuphezulu kwe-ERRα, i-ERRβ kunye ne-ERRγ kunye namaxabiso e-EC50 angama-98 nM, 230 nM kunye ne-430 nM ngokwahlukeneyo. Le compound inokuphucula ukusebenza kwe-mitochondrial kunye nokuphefumla kweseli kwimigca yeseli yemisipha yamathambo, esetyenziswa kakhulu kuphando lwelebhu yezemfundo kunye nophando lwendlela yokwenza amayeza.
Iimpawu zeMveliso
✅ Ubunyulu obuphezulu, buvavanywe yi-HPLC, buzinzile kwaye buhambelana nebhetshi nganye
✅ Cacisa idatha yomsebenzi webhayoloji yophando olujoliswe kwi-ERR
✅ Iphakheji encinci yelebhu iyafumaneka, i-odolo yesampulu yenkxaso
✅ Ukunyibilika okuhle kwi-DMSO kwifomyula yovavanyo lweseli
✅ Ukupakisha okungqongqo okungenakukhanya kubushushu obuphantsi ukuze kugcinwe ixesha elide
| Into | Iinkcukacha |
| Inkangeleko | Umgubo ocolekileyo omhlophe ukuya komhlophe kakhulu |
| Ibanga | I-Reagent yeBanga loPhando / yeLebhu |
| Ubunyulu | 98% Ubuncinci / 99% Ubuncinci (HPLC) |
| Isicelo | Uphando lwelebhu kuphela |
| Isaziso | Ukusetyenziswa koPhando kuphela, kungekhona okomntu |
| Beka ubomi kwishelufa | Isithuba seenyanga ezingama-24 sigcinwe kakuhle |
1. Uphando lwezeMfundo kunye neLebhu:
Isetyenziswa kakhulu ekufundeni indlela yokubonisa i-ERR, umsebenzi we-mitochondrial, uphando lwe-metabolism yemisipha yamathambo.
2. Uphononongo lweKhemistry:
Isetyenziselwa uphando lwendlela yokuphazamiseka kwemetabolism, ukutyeba kakhulu, ukungasebenzi kakuhle kwemisipha okunxulumene nokwaluphala; ilinganisa impendulo yezakhi zofuzo ezinxulumene nomthambo we-aerobic kwiimvavanyo zangaphambi kweklinikhi zeeseli kunye neemodeli zezilwanyana. Kwi....
3. Uphando noPhuhliso lwezeMpilo:
Isixhobo esincedisayo sokuhlola iithagethi ezintsha zamayeza, iimvavanyo zesayensi ezisisiseko kwiilabhoratri zaseyunivesithi kunye namaziko ophando.
• Ukupakisha okuqhelekileyo: 25 kg/ibhegi;
• I-MOQ: kufuneka iqinisekiswe ngokwebanga nendawo ekuyiwa kuyo
• Ixesha lokuKhokhela: liza kuqinisekiswa ngobungakanani beodolo kunye neshedyuli yemveliso
• Ukuthunyelwa: ukhetho lolwandle / lomoya / olukhawulezayo luyafumaneka
• Gcina kwindawo epholileyo, eyomileyo, nengena umoya kakuhle.
• Gcina isitya sivaliwe kakuhle kwaye sikhuselekile kumswakama.
• Kuphephe ukukhanya kwelanga ngqo, ubushushu, kunye nomlilo ovulekileyo.
• Landela isikhokelo se-SDS kwizinto ezingahambelaniyo.
