I-Polycaprolactone CAS 24980-41-4

I. Intsimi yokuPrinta ye-3D: Izinto ezisetyenziswayo ezifanelekileyo ukuze kube nokuchaneka okuphezulu kunye nokwenza ngokwezifiso

Kwicandelo lokuprinta nge-3D (ukwenziwa kwezinto ezongezelelweyo), i-polycaprolactone PCL ibe yenye yezinto eziphambili zokuprinta nge-3D ezinokubola ngenxa yokuba iphantsi kakhulu ekunyibilikeni (malunga ne-60℃), ukunyibilika kakuhle kokunyibilika kunye namandla okubopha phakathi kweeleya. I-PCL polymer ifanelekile ngokukodwa kwiindlela zobugcisa ezifana ne-fused Deposition modeling (FDM) kunye ne-sterolithography, kwaye isetyenziswa kakhulu kwezi meko zilandelayo:

Imodeli eyenzelwe wena kunye nokwenziwa kweeprototype:I-Polycaprolactone PCL inobushushu obuphakathi bokujika ubushushu, nto leyo eyenza ukuba ingabi nakwenzeka ukuba igobe okanye iqhekeke ngexesha lenkqubo yokuprinta. Ingaphinda ngokuchanekileyo izakhiwo ezintsonkothileyo (ezifana neeprototypes zenxalenye yoomatshini kunye neemodeli ezincinci zokwakha), kwaye iindawo eziprintiweyo zinobukhazikhazi obuphezulu, obungafuni ukucutshungulwa kakhulu emva kokusetyenziswa. Okwangoku, ipropati ewohlokayo yePolycaprolactone PCL iyenza ifaneleke kwiimeko zeprototype "ezisetyenziswa kanye" (ezifana neemodeli zovavanyo lwezixhobo zeemoto), ukunciphisa inkunkuma yezinto.

Ukuprinta kwe-3D ye-biomedical Njengesixhobo esinokuhambelana okugqwesileyo kwezinto eziphilayo:I-polycaprolactone PCL ivelele ekuprintweni kwee-scaffolds zobunjineli bezicubu. Ngokulungisa ubunzima beemolekyuli zezinto okanye ngokuzidibanisa nezinto ezisebenzayo eziphilayo ezifana ne-hydroxyapatite (HA) kunye ne-collagen, ii-scaffolds ezinemibhobho ezihambelana neemfuno zokukhula kwezicubu ezifana namathambo kunye ne-cartilage zinokulungiswa. I-scaffold inokonakala kancinci emzimbeni, inike indawo yokuxhasa izicubu ezintsha. Okwangoku, i-PCL polymer isetyenzisiwe kuphando lokushicilela lwezonyango olufana nokulungiswa kwamathambo kunye nokuvuselelwa kolusu.

Kwimimandla yemfundo nobuchule:Iqondo eliphantsi lokunyibilika kwe-polycaprolactone PCL lenza ukuba kuprintwe ngaphandle kwesidingo sezixhobo ezishushu kakhulu, okuqinisekisa ukhuseleko oluphezulu. Ifanelekile njengesixhobo sokwazisa sokuprinta kwe-3D kwiimeko zemfundo. I-polycaprolactone PCL isetyenziselwa ukwenza iimodeli zokufundisa (ezifana neemodeli zezitho zomntu kunye neemodeli zesakhiwo semolekyuli yeekhemikhali). Okwangoku, uphawu lwayo lokuguquguquka kancinci kubushushu begumbi lukwaxhasa intsimi yoyilo lobuchule ekwenzeni ukufakelwa kobugcisa okanye izixhobo zokudlala ezineemilo ezihlengahlengiswayo.

Ii. Indawo yokuPakisha Ukutya Okulahlwayo: Iziqinisekiso ezimbini zokuwohloka kohlaza kunye nokukhuselwa kokhuseleko

Kwicandelo lokupakisha ukutya okulahlwayo, i-polycaprolactone PCL ibe yindlela ebalulekileyo yokukhetha iiplastiki zemveli ezingaboliyo (ezifana ne-polyethylene kunye ne-polypropylene) ngenxa yokuba ibolile ngokupheleleyo, iipropati ezilungileyo zokuthintela kunye nokhuseleko lokudibana nokutya, okunceda ukusombulula ingxaki "yongcoliseko olumhlophe". Iifom zayo eziphambili zokufaka isicelo ziquka

Ifilimu/ibhegi yokupakisha ukutya ebolayo:I-PCL ingaxutywa kwaye iguqulwe ngezinto ze-polymer zendalo ezifana nesitatshi kunye ne-polylactic acid (PLA) ukuphucula ukuguquguquka kunye nokumelana namanzi kwezinto, kwaye zenziwe iifilimu okanye iingxowa zokugcina ukutya okutsha (ezifana neziqhamo nemifuno) kunye nokutya okuphekiweyo - olu hlobo lokupakisha lungasetyenziswa kwiindawo zendalo (ezifana nomhlaba kunye neemeko zomgquba) i-polycaprolactone PCL inokonakala kancinci kancinci ibe yi-carbon dioxide namanzi kwisithuba seenyanga ezi-6 ukuya kwezili-12 ngaphandle kokushiya naluphi na ungcoliseko olushiyekileyo. Okwangoku, i-PCL polymer inozinzo oluhle kakhulu lweekhemikhali kwaye ayisebenzi neeoyile okanye izinto ezine-asidi ekutyeni, ihlangabezana nemigangatho yokhuseleko lwezinto zokudibanisa ukutya (ezifana nesiqinisekiso se-FDA).

Izikhongozeli zokutya ezilahlwayo kunye nezitya zokutya:Ngokusebenzisa iinkqubo zokubumba ngenaliti okanye zokucinezela ngobushushu, i-polycaprolactone PCL inokuhlanganiswa neefayibha zezityalo (ezifana neefayibha zengca, iifayibha ze-bamboo) ukuvelisa iibhokisi zesidlo sasemini ezilahlwayo, iipleyiti, iimela, iifolokhwe kunye nezinye iimveliso. Olu hlobo lwemveliso alunawo nje kuphela amandla okuthwala umthwalo kunye nokumelana nobushushu (luyakwazi ukumelana namaqondo obushushu okutya ashushu angama-60-80℃), kodwa i-PCL polymer inokonakala ngokusebenzisa umgquba emva kokusetyenziswa, kuthintelwe ungcoliseko lwendalo oluhlala ixesha elide olubangelwa zizinto zeplastiki zendabuko. Ifanelekile ngokukodwa kwiimeko zokupakisha ezilahlwayo ezilahlwayo ezidla ngokufumaneka rhoqo ezifana nokutya okutyayo kunye nokutya okukhawulezayo.

Iii. Intsimi yeZixhobo zePhepha lezonyango: Izinto eziphambili zokuhambelana kwezinto eziphilayo kunye nokuziqhelanisa nokusebenza

Kwicandelo leepleyiti zonyango, i-polycaprolactone (PCL) iye yaba yinto ephambili yokwenza iipleyiti zokulungisa unyango kunye neepleyiti zokukhusela ngenxa yokhuseleko lwayo olubalaseleyo lwezinto eziphilayo, izinga lokuwohloka elilawulekayo kunye neempawu zoomatshini. Imiyalelo yayo ephambili yokusebenzisa ibandakanya:

Iibhodi zokulungisa unyango:Kwimimandla efana ne-orthopedics kunye ne-dentistry, i-polycaprolactone PCL inokonyusa amandla ayo oomatshini ngokuguqula (njengokudibanisa i-hydroxyapatite kunye ne-triccalcium phosphate), kwaye yenziwe ibe ziibhodi zokulungisa iziphene zamathambo kunye neebhodi zokuvuselela amathambo e-alveolar. Emva kokufakelwa emzimbeni womntu, olu hlobo lwebhodi alunakubonelela ngenkxaso ekhawulezileyo kuphela kumathambo awonakeleyo kodwa lukwawohloka kancinci kancinci kunye nokuvuselelwa kwamathambo omzimba, kuthintelwe umngcipheko wotyando lwesibini lokususwa. Okwangoku, ukuhambelana kwe-polycaprolactone PCL kunokunciphisa ukwaliwa komzimba emva kokufakelwa, kukhuthaze ukunamathela kweseli kunye nokuhlanganiswa kwezicubu, kwaye kusetyenziswe ngokwezonyango kwiindlela ezincinci zokulungisa amathambo.

Iibhodi zokukhusela nokwahlukanisa ezonyango:I-PCL ineempawu ezintle kakhulu zokwenza ifilimu kunye nezithintelo kwaye ingenziwa ibe ziibhodi zokwahlukanisa zonyango (ezifana neebhodi zokukhusela udonga zamagumbi okusebenzela kunye neengqimba zokwahlukanisa umphezulu wezixhobo zonyango). Olu hlobo lwebhodi alugcini nje ngokuthintela ngempumelelo ukungena kweebhaktheriya kunye neentsholongwane, kodwa lukwanokuguquguquka okuthile kunye nokumelana nokubulala iintsholongwane. Ingakwazi ukumelana nokusula ngokuphindaphindiweyo ngezibulali-ntsholongwane ezine-alcohol kunye ne-chlorine, kwaye iyabola emva kokulahlwa, inciphisa uxinzelelo lonyango lwenkunkuma yezonyango. Ukongeza, i-polycaprolactone PCL inokudityaniswa neearhente zokulwa neentsholongwane (ezifana nee-silver ions) ukuphucula ngakumbi ukusebenza kweebhodi zokukhusela ezikhuselayo okuhlala ixesha elide, okwenza ukuba ifaneleke kwiimeko ezineemfuno eziphezulu kakhulu zokucoceka kokusingqongileyo, ezifana namasebe ezifo ezisulelayo kunye ne-icus.

Iv. Ezinye iiNdawo: iiNdawo zolwandiso ezisebenzayo

Ukongeza kwiindawo eziphambili ezikhankanyiweyo apha ngasentla, i-polycaprolactone PCL ikwadlala indima kwiimeko ezininzi:

Iingubo kunye nezinto zokuncamathelisa:I-polycaprolactone PCL, njengenxalenye ephambili yokwenza ifilimu yengubo esekwe emanzini okanye kwi-solvent-based, inokuphucula ukuguquguquka, ukumelana nempembelelo kunye nokumelana nemozulu kwengubo - umzekelo, xa isetyenziswa kwingubo yangaphandle yodonga lwemibhobho yesinyithi, inokunciphisa ukuqhekeka kwengubo ebangelwa kukuxinana kwemibhobho ngenxa yotshintsho lobushushu. I-polycaprolactone PCL isetyenziswa njengengubo yomphezulu wezinto zokudlala zeplastiki, okwenza ingubo ingagugi kwaye ingatyeki kakhulu ekuqhekekeni. Ngaphezu koko, njengoko i-PCL ngokwayo ingenatyhefu, inokuhlangabezana nemigangatho yokhuseleko lwezinto zokudlala zabantwana. Ukongeza, ukongeza i-polymer ye-PCL kwiingubo zomthi kunokuphucula ukubonakaliswa kombala weenkozo zomthi kunye nokuphucula ukubonakala.

Izixhobo zolimo:I-polycaprolactone PCL yenziwe ngeefilimu zezolimo ezibolayo, ezisetyenziselwa ukukhulisa izithole zezityalo, ukugcina amanzi kunye nezichumisi. Emva kokubola, zinokuguqulwa zibe zizinto eziphilayo zomhlaba, kuthintelwe ungcoliseko lomhlaba olubangelwa ziifilimu eziseleyo. Okanye ingenziwa ibe yithwali yesichumisi ekhupha kancinci ukulawula izinga lokukhululwa kwezondlo, kwaye i-PCL polymer inokuphucula izinga lokusetyenziswa kwesichumisi. Uphawu "lokubola olulawulekayo" lwe-PCL luhlangabezana ngokugqibeleleyo neemfuno zezolimo "zokusebenza" kunye "nobuhlobo nokusingqongileyo", kwaye lusetyenziswa kakhulu ukusombulula iingxaki zongcoliseko lwezixhobo zezolimo zemveli.

Isilungisi sezinto ezidityanisiweyo:I-polycaprolactone PCL ixutywe nee-polyolefins, i-polyester kunye nezinye izinto ukuphucula ukuguquguquka kwazo kunye namandla azo okuchaphazela, okwenza ukuba ifaneleke kwiimeko ezineemfuno eziphezulu zokusebenza kwezinto, ezifana nezixhobo zangaphakathi zeemoto kunye namaqokobhe ezixhobo zasekhaya.

Ukuguqulwa kwefayibha/Ilaphu:I-polycaprolactone PCL isetyenziselwa ukugquma okanye ukuguqula imicu ye-polyester kunye nekotoni ukuze kuphuculwe ukuthamba kwayo, ukumelana nokuguguleka kunye neempawu zokulwa nemibimbi. Umzekelo, ukongeza i-PCL coating kwimpahla yezemidlalo kunokwenza imicu ikwazi ukunwebeka kwaye ingaguquguquki. Ukudibanisa i-PCL kwimicu ye-gauze yezonyango kunokuphucula ukufunxwa komswakama kunye nokugcinwa kwe-gauze, kuphucule ukunamathela kwayo eluswini, kwaye kunciphise ukungonwabi okubangelwa kukungqubana kwamanxeba.