iindaba

I. Intshayelelo

I-Unilong ngumvelisi ochwephesha kunye nomthengisi wezithako zobuhle ezisebenza kakuhle, onikezela ngeqhayiyaIHinokitiol (CAS 499-44-5)– eyaziwa ngokuba yi-β-thujaplicin – ikwimo yokwenziwa ngobunyulu obuphezulu. Ngokungafaniyo ne-hinokitiol yendalo ekhutshwe kwimithombo yemithi yeCupressaceae enomda kwaye inobuthathaka kokusingqongileyo, i-hinokitiol yethu yokwenziwa inika isakhiwo esifanayo seekhemikhali kunye nomsebenzi webhayoloji ngomgangatho ohambelanayo, unikezelo oluzinzileyo, kunye namaxabiso akhuphisanayo. Njenge-monoterpenoid esebenza ngeendlela ezininzi eneempawu ezinamandla zokulwa neentsholongwane, ukubola, i-antioxidant, ukulwa nokuvuvukala, kunye nokukhanyisa ulusu, i-hinokitiol ivele njengesithako esibalaseleyo kukhathalelo lolusu lwanamhlanje. Nokuba wenza unyango lwe-acne, ii-serum zokulwa nokwaluphala, iimveliso zokukhanyisa, okanye iinkqubo zokukhulisa ulondolozo, i-hinokitiol yokwenziwa ye-Unilong inikezela ngokusebenza okufunekayo ngokuthembeka okulindeleyo.

II. Isishwankathelo seMveliso

IHinokitiol (CAS 499-44-5), eyaziwa ngokuba yii-β-thujaplicin, yi-monoterpenoid yendalo eyinxalenye yosapho lwe-tropolone. Ekuqaleni yayihlukaniswe kwi-heartwood yemithi yeCupressaceae efana neTaiwan hinoki (Chamaecyparis taiwanensis) kunye ne-Japanese cypress (Aomori Hiba). Ngefomula ye-molecular ye-C10H12O2 kunye nobunzima be-molecular obumalunga ne-164.20 g/mol, i-hinokitiol inesakhiwo sendandatho ye-tropolone eyahlukileyo enoxanduva lwemisebenzi yayo emangalisayo yebhayoloji.

III. Ukusebenza okuPhambili kunye neeNzuzo

1. Umsebenzi we-Antimicrobial obanzi

I-Hinokitiol inefuthe elinamandla lokulwa neentsholongwane kwiintsholongwane ezahlukeneyo, iifungi, kwaneentsholongwane ezithile. Indlela esebenza ngayo ibandakanya ukuphazamisa ukuthembeka kwe-membrane yeseli ngokunciphisa umxholo we-ergosterol kwii-membrane ze-fungus kunye nokwandisa ukungena kwe-membrane. Okuphawulekayo kukuba, i-hinokitiol ibonakalise ukusebenza okumangalisayo ngokuchasene ne-Methicillin-resistant Staphylococcus aureus (MRSA) - i-pathogen efumaneka rhoqo kulusu lomntu nakwiindlela zokuphefumla ezinokubangela usulelo olukhulu lolusu, i-sepsis, kunye netyhefu yokutya.

(1) Ukulwa neebhaktheriya: Isebenza kakuhle kwiibhaktheriya ezineGram-positive kuquka i-S. aureus kunye ne-MRSA

(2) Ukulwa neefungi: Ithintela i-Aspergillus fumigatus, iintlobo zeCandida, i-Aspergillus niger, kunye nePenicillium citrinum

(3) Ubuthi obukhethiweyo: Izifundo zibonisa ukuba i-hinokitiol ibonakalisa ulwalamano oluqinileyo nee-membranes zebhaktiriya kuneeseli zesikhumba sezilwanyana ezincancisayo, nto leyo eyenza ikhuseleke ukusetyenziswa kwayo endaweni yokuthambisa.

2. Umsebenzi we-Antioxidant onamandla

I-Hinokitiol isebenza njenge-antioxidant enamandla, icima ngempumelelo ii-free radicals eziveliswa zizinto ezingcolisayo kokusingqongileyo kunye neenkqubo zokudumba. Ngokuthomalalisa iintlobo ze-oxygen ezisebenzayo (i-ROS), inceda ekuthinteleni ukuguga kolusu ngaphambi kwexesha, inciphisa umonakalo we-oxidative, kwaye ikhusela umqobo wolusu. Le mandla ye-antioxidant ihambelana nezinye izibonelelo zayo zolusu, okwenza ibe sisithako esipheleleyo sokulwa nokwaluphala.

3. Lawula iipropati zokulwa nokudumba

Ngaphandle kwemiphumo yokulwa neentsholongwane kunye ne-antioxidant, i-hinokitiol inomsebenzi obalulekileyo wokulwa nokuvuvukala. Uphando lubonise amandla ayo okuguqula iindlela zokuvuvukala, kubandakanya indlela yokubonisa i-TLR4/MyD88, okwenza ukuba isebenze ekunciphiseni ukudumba okunxulunyaniswa ne-atopic dermatitis (eczema) kunye nezinye iimeko zolusu ezivuthayo. Oku kwenza i-hinokitiol ixabiseke ngakumbi kwiintlobo zolusu ezibuthathaka nezisabelayo.

4. Ukukhanya kolusu kunye nokuthintelwa kweMelanin

IHinokitiolKuye kwabonakala ukuba ithintela imveliso ye-melanin ngokunciphisa umsebenzi we-tyrosinase, isebenza njengearhente yokukhanyisa yebhayoloji kumabala amnyama, amabala okuguga, kunye nokuphakama kombala. Le ntshukumo imbini - ekhanyayo ngelixa ibonelela ngeenzuzo zokulwa neentsholongwane kunye nokulwa nokuvuvukala - yenza ukuba ibe sisithako esikhethekileyo sokuphucula ithoni yolusu ngokubanzi.

5. I-Iron Chelation kunye neenzuzo zeSeli

Njenge-iron chelator, i-hinokitiol inokuguqula amanqanaba e-iron yeselula - uphawu oluye lwanxulunyaniswa nemiphumo emihle ekuhlukaniseni i-keratinocyte kunye nempilo yolusu iyonke. Le ndlela ikhethekileyo yongeza olunye ulwahlulo kwiprofayili yayo yemisebenzi emininzi.

6. Ukunyusa Izithinteli Zendalo

Iimpawu zeHinokitiol zokulwa neentsholongwane zenza ukuba ibe sisixhobo esisebenzayo sokukhusela izinto eziphilayo kwizithambiso zendalo. Inokunceda ekunciphiseni ukuxhomekeka kwizithintelo zokwenziwa, ixhasa "ubuhle obucocekileyo" kunye neengcamango zemveliso "engenazo izithintelo" ngelixa igcina ukhuseleko lweentsholongwane.

IV. Iindawo eziPhambili zoSetyenziso

1. Ulusu olune-acne kunye ne-palesabled skin

IHinokitiolIbonakalise amandla amangalisayo ekunyangeni i-acne, i-eczema, kunye nezinye iimeko zolusu ezivuthayo ngokunciphisa ukukhula kweentsholongwane ngelixa ngaxeshanye ithomalalisa ukudumba. Umsebenzi wayo onamandla wokulwa neentsholongwane ngokuchasene neebhaktheriya ezibangela i-acne (kuquka i-C. acnes kunye ne-S. aureus) unceda ukunciphisa ukudumba kwaye ukhuthaze ulusu olucacileyo. Iimpawu zokulwa nokudumba zinceda ngakumbi ukuzola amabala akhoyo kwaye zithintele i-hyperpigmentation emva kokudumba.

2. Ukulwa nokwaluphala kunye nokuvuselelwa kolusu

Ngenxa yomsebenzi wayo onamandla we-antioxidant, i-hinokitiol inceda ekunciphiseni ii-free radicals ezibangela ukwaluphala kwangethuba. Iphucula ulusu, inciphisa ukubonakala kwemigca emincinci kunye nemibimbi, kwaye ikhuthaza umbala wolusu oluncinci ngakumbi. Amandla ayo okuxhasa impilo yolusu ngelixa ibonelela ngokhuseleko lwe-UV aphucula ngakumbi ixabiso layo kwi-anti-aging formulations.

3. Ulusu olukhazimlayo kunye nethoni elinganayo

Amandla eHinokitiol okuthintela ukuveliswa kwe-melanin ayenza ibe sisithako esibalulekileyo kwiimveliso ezikhanyisayo nezilungisa amabala. Inceda ukulingana kombala wolusu, inciphise ukubonakala kwamabala amnyama kunye namabala okuguga, kwaye ikhuthaze umbala okhanyayo. Oku kuyenza ifaneleke ngakumbi xa idityaniswe nezinye izinto ezikhanyisayo ukuze kubekho iziphumo ezihambelanayo.

4. Ukhathalelo lwesikhumba esibuthathaka kunye ne-eczema

Iimpawu zeHinokitiol zokulwa nokuvuvukala kunye nomsebenzi wayo wokubulala iintsholongwane okhethiweyo zenza ukuba ilungele ukusetyenziswa kwesikhumba esinobuthathaka. Izifundo zibonise ukusebenza kwayo ekunciphiseni ukudumba kwiimodeli ze-atopic dermatitis. Ngokungafaniyo neearhente ezinobungozi zokulwa neentsholongwane ezinokuphazamisa i-microbiome yolusu, i-hinokitiol inika indlela ethambileyo kodwa esebenzayo yokulawula iimeko zolusu ezinobuthathaka nezisabelayo.

5. Ukhathalelo lwentloko kunye neenwele

Iimpawu zeHinokitiol zokulwa neentsholongwane kunye nokulwa nokuvuvukala zisebenza nakwiindawo zokhathalelo lwentloko. Inceda ekulweni neefungi ezibangela inkwethu, ithomalalisa ukurhawuzelelwa kwentloko, kwaye ikhuthaza indawo esempilweni yentloko - zonke ezi zinto zibalulekile ekukhuleni nasekubukekeni kweenwele kakuhle.

6. Ukhathalelo Lomlomo

I-Hinokitiol isetyenzisiwe kwi-toothpaste nakwi-mouthwash ngenxa yeempawu zayo zokulwa neentsholongwane. Inceda ekunciphiseni iintsholongwane zomlomo, ithintele ukwakheka kwe-plaque, kwaye ikhuthaza impilo yeentsini.

7. Iinkqubo zeNdalo zoLondolozo

Njengesixhobo sokunyusa isithinteli sendalo, i-hinokitiol ingafakwa kwiifomyula zokuphucula uzinzo lweentsholongwane ngelixa ixhasa amabango "elebheli ecocekileyo". Isebenza ngokubambisana nezinye izithinteli, ivumela ukuncipha koxinzelelo lwezithinteli zokwenziwa.

V. Iinkcukacha zobugcisa

VI. Isishwankathelo

Nokuba wenza unyango lwe-acne, ii-serum zokulwa nokwaluphala, iimveliso zokukhanyisa, ukhathalelo lwentloko, okanye iinkqubo zendalo zokugcina ulusu,I-Hinokitiol yokwenziwa ye-Unilong(≥99%) inika ukusebenza okunemisebenzi emininzi efunekayo kwiifomyula zakho - ngokuthembeka kokubonelela kunye nokusebenza kakuhle kweendleko okunikezelwa yimveliso yokwenziwa.

Qhagamshelana nathi namhlanje ukuze ufumane iisampulu, iiSheets zeDatha yoBugcisa (i-TDS), okanye iiSheets zeDatha yoKhuseleko (i-SDS)!