Ukuhlolwa koMgangatho wokuHanjiswa ngokukhawuleza kunye nokuPhuculwa okuPhezulu kweCAS 93-02-7 2, 5-Dimethoxybenzaldehyde

Silwela ukugqwesa, inkonzo kubathengi”, sinethemba lokuba lelona qela lentsebenziswano libalaseleyo kunye neshishini elilawulayo kubasebenzi, ababoneleli kunye nabathengi, baqonda isabelo sexabiso kunye nokukhuthaza okuqhubekayo kokuHlolwa koMgangatho wokuHanjiswa okuKhawuleza kunye nokuPhuculwa okuPhezulu kweCAS 93-02-7 2, 5-Dimethoxybenzaldehyde, Siza kubonelela ngowona mgangatho uphezulu usebenzayo, ngokuqinisekileyo elona xabiso linamandla kwicandelo, kubathengi abatsha nabandala abanezona nkonzo zibalaseleyo zohlaza.
Silwela ukugqwesa, inkonzo kubathengi”, sinethemba lokuba lelona qela lentsebenziswano libalaseleyo kunye neshishini elilawulayo kubasebenzi, ababoneleli kunye nabathengi, ukuqonda isabelo sexabiso kunye nokukhuthaza okuqhubekayoChina Chemical Intermediates kunye Pharmaceutical Raw Materials, Ngenxa yokutshintsha kweendlela kulo mba, sizibandakanya kurhwebo lokuthengisa ngeenzame ezizinikeleyo kunye nokugqwesa kolawulo. Sigcina iishedyuli zokuhanjiswa kwangexesha, uyilo oluyilayo, umgangatho kunye nokungafihlisi kubathengi bethu. Imoto yethu kukuzisa izisombululo ezisemgangathweni ngexesha elibekiweyo.

I-2,5-i-Dimethoxybenzaldehyde yi-crystalline powder ekhanyayo kunye ne-molecular weight ye-166.18 kunye neqondo lokubilisa le-146 ° C. Iyanyibilika kwizinyibilikisi zendalo ezifana ne-ethanol kunye ne-ether. Isetyenziswa ikakhulu njenge pharmaceutical intermediate.

Ukongeza kwi-oxidized okanye ukunciphisa i-2,5-dimethoxybenzoic acid, i-benzonitrile okanye i-benzyl alcohol, i-2,5-dimethoxybenzaldehyde ngokwayo nayo inexabiso elilodwa lesicelo. Ngokuphendula ngezinto ezineentlobo ezahlukeneyo zamaqela asebenzayo, iimolekyuli zamachiza ezinezakhiwo ezahlukeneyo kunye nemiphumo eyahlukeneyo inokufumaneka. Isifo sikaParkinson (PD) sisifo esiqhelekileyo se-neurodeergenerative, kwaye iimpawu zaso eziphambili zeklinikhi ziquka ukungcangcazela kwemisipha, ukuqina, ubunzima bokuhamba, ukuma komzimba kunye nokuphazamiseka kokuhamba kakuhle. Uphuhliso olongezelelweyo luya kukhokelela ekuqaphelisweni, ukuqonda, ukuphazamiseka kwememori kunye nesifo sengqondo esixhalabisayo. Okwangoku, unyango lwePD ikakhulu lubandakanya unyango lweziyobisi, unyango lotyando kunye nonyango lwemfuza. Kunyango lweziyobisi, i-phenamidine ifunyenwe ibe nefuthe elihle kwi-PD, enetyhefu ephantsi kunye nokhuseleko oluhle, kwaye i-synthesis ye-phenamidine idinga ukusetyenziswa kwe-2,5-dimethoxybenzaldehyde njengento yokuqala.

Ngokwendlela yokudibanisa echazwe kwiincwadi, i-2,5-dimethoxybenzaldehyde ifunyenwe ngokuyiphendulela i-1,4-dimethoxybenzene kunye ne-agent ye-formylation. I-Formylation agents ziquka (1) umxube we-1,1-dichloromethyl ether kunye ne-titanium tetrachloride; (2) umxube we-N, N-dimethylformamide kunye ne-phosphorus oxychloride, umxube we-N, N-dimethylformamide kunye ne-oxalyl chloride; (3) umxube we-N, N-dimethylformamide kunye ne-thionyl chloride okanye umxube we-urotropine kunye ne-magnesium chloride. Nangona kunjalo, ezi ndlela zifuna ukusetyenziswa kwesixa esikhulu se-titanium tetrachloride, i-phosphorus oxychloride okanye i-thionyl chloride. Ezi reagents aziqinisekanga kwaye zibole ngokulula, kwaye isixa esikhulu segesi ye-hydrochloric acid ikhutshwa ngexesha lokuphendula, elingenabume bendalo kwaye lineemfuno eziphezulu zenkqubo yokusebenza.

Kuye kwacetywa indlela entsha yokudibanisa. Le ndlela isebenzisa i-1,4-dimethoxybenzene kunye ne-formaldehyde njengezinto eziluhlaza, kwaye yenza i-photooxidative coupling reaction phambi kwe-oksijini kunye ne-catalyst phantsi kwe-irradiation yokukhanya okuluhlaza okwesibhakabhaka ukwenza ngokufanelekileyo i-2,5-dimethoxybenzaldehyde. Le ndlela isebenzisa ioksijini okanye umoya njenge-oxidant, ayivelisi igesi eneasidi, kwaye ihambelana nokusingqongileyo. Ukongeza, le ndlela isebenzisa i-cobalt encinci njenge-catalyst, ephantsi kwexabiso kwaye ifanele ukusetyenziswa kwezoshishino.

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Silwela ukugqwesa, inkonzo kubathengi”, sinethemba lokuba lelona qela lentsebenziswano libalaseleyo kunye neshishini elilawulayo kubasebenzi, ababoneleli kunye nabathengi, baqonda isabelo sexabiso kunye nokukhuthaza okuqhubekayo kokuHlolwa koMgangatho wokuHanjiswa okuKhawuleza kunye nokuPhuculwa okuPhezulu kweCAS 93-02-7 2, 5-Dimethoxybenzaldehyde, Siza kubonelela ngowona mgangatho uphezulu usebenzayo, ngokuqinisekileyo elona xabiso linamandla kwicandelo, kubathengi abatsha nabandala abanezona nkonzo zibalaseleyo zohlaza.
Ukuhlolwa koMgangatho weChina Chemical Intermediates kunye Pharmaceutical Raw Materials, Ngenxa yokutshintsha kweendlela kulo mba, sizibandakanya kurhwebo lokuthengisa ngeenzame ezizinikeleyo kunye nokugqwesa kolawulo. Sigcina iishedyuli zokuhanjiswa kwangexesha, uyilo oluyilayo, umgangatho kunye nokungafihlisi kubathengi bethu. Imoto yethu kukuzisa izisombululo ezisemgangathweni ngexesha elibekiweyo.