iindaba

I-PolyvinylpyrrolidoneUlwakhiwo lwekhemikhali (PVP) lunendandatho ye-pyrrolidone, enika ukunyibilika kwamanzi okugqwesileyo, amandla okwenza ifilimu, ukunamathela, kunye nokuhambelana kwezinto eziphilayo.

I-“K25″ kwi-PVP K25 imele umgangatho wayo wobunzima beemolekyuli, apho “ixabiso le-K” liyimbonakaliso ephambili yobunzima beemolekyuli ze-PVP. Ixabiso eliphezulu le-K lihambelana nobunzima beemolekyuli obuphezulu kunye ne-viscosity. I-K25 iwela kuluhlu lobunzima beemolekyuli oluphakathi nolusezantsi, lubonisa ukunyibilika okubalaseleyo kwizinyibilikisi ezifana namanzi, i-ethanol, kunye ne-acetone.

Izicelo eziphambili zePVP K25

Ngenxa yobunzima bayo obulungeleleneyo beemolekyuli, iipropati zokuncamathelisa, kunye nokunyibilika,I-PVP K25isetyenziswa kakhulu kumayeza, izinto zokuthambisa, kunye namacandelo emizi-mveliso:

Intsimi yeMithi

I-Tablet Binder: Inyibilikiswe emanzini okanye kwi-ethanol, inceda ukuba imiphunga yamayeza ihlangane ibe ziigranules, nto leyo ephucula ubulukhuni bepilisi kunye nokuqhekeka kwayo.

Isinyibilikisi kunye neDispersant: Iphucula ukunyibilika kwamayeza anganyibilikiyo kakuhle ngokwenza ii-complexes, ngaloo ndlela inyusa ukufumaneka kwezinto eziphilayo.

Ifilimu yangaphambili: Isetyenziswa kwiifomyula ezikhutshwa ngokulawulwayo okanye kwiipatches zesikhumba ukulawula ukukhutshwa kwamayeza.

Izinto zokuthambisa kunye nokhathalelo lomntu

Ukhathalelo lolusu kunye nokhathalelo lweenwele: Isebenza njengesithambisi, isizinzisi, okanye i-film, iphucula ubume bemveliso kwaye iqinisekisa ukusasazwa ngokulinganayo kwezithako ezisebenzayo.

Iimveliso zokuhombisa iinwele (umz., iijeli zeenwele, iimascara): Inika ukubamba okuqinileyo kwaye kulula ukuyisusa ngenxa yeempawu zayo zokwenza ifilimu kunye nokunyibilika emanzini.

Izicelo zeMveliso

Iingubo kunye nee-Inks: Isebenza njengesinyibilikisi kunye nesityebisi, iqinisa imibala kwaye iphucula ukunamathela kwengubo.

Ishishini leempahla: Lisetyenziselwa unyango lwelaphu ukuphucula ukuguquguquka nokusebenza okungenazimo.

Izixhobo ze-elektroniki: Zisebenza njengesihlanganisi okanye isisasazi xa kusenziwa ibhetri okanye izinto, ziqinisekisa ukuba i-electrode coating iyafana.

Ukusebenza kakuhle kwePVP K25 kugqwesile

Njengento yokuncamathelisa yamayeza eqhelekileyo, inzuzo ephambili yePVP K25 ikwi "bhalansi" phakathi kwamandla ayo okunamathela kunye ne-viscosity yesisombululo:

Ukunamathela okuphezulu, okuqinisekisa ukuthembeka kwethebhulethi: Ingadibanisa ngempumelelo iipowder zamayeza kunye nezinto ezincedisayo (ezifana nezizalisi, ii-disintegrants), zenze amasuntswana azinzileyo ngokwesakhiwo. Ubunzima beetablethi ezicinezelweyo buhlangabezana nomgangatho kwaye azinangxaki yokuba buthathaka, nto leyo enciphisa iingxaki ezifana neetablethi eziqhekekileyo nezikhululekileyo ngexesha lenkqubo yokuvelisa. Ifanelekile ngakumbi kwiitablethi ezineemfuno zokuqina kokunamathela (ezifana neetablethi zamayeza ezinomthamo ophezulu kunye neetablethi zepowders ezinzima ukumila).

I-viscosity yesisombululo esiphantsi, kulula ukuyinyibilikisa nokuyiphatha Xa kuthelekiswa neemodeli eziphezulu ze-PVP (ezifana ne-PVP K30, i-PVP K90), i-K25 inobunzima obuphantsi be-molecular. Isisombululo sayo samanzi okanye isisombululo se-organic (esifana ne-ethanol) sinobunzima obuphantsi, sinyibilika ngokukhawuleza, kwaye akunakwenzeka ukuba senze "amaqhuma" ngexesha le-granulation, nto leyo eyenza kube lula ukuxubana okufanayo. Kwangaxeshanye, inciphisa ubunzima bokusebenza kwezixhobo (ezifana ne-granulators, ii-tablet presses) kwaye iphucula ukusebenza kakuhle kwemveliso.

Ikhuselekile kangakanani iPVP K25

I-PVP K25sisithako samayeza esinokhuseleko oluqinisekisiweyo ngokupheleleyo, sihlangabezana nemigangatho ye-pharmacopoeia yamazwe amaninzi kwihlabathi liphela. Idatha yetyhefu ixhasa ubuthi bayo obuphantsi, ukungaqokeleli, kunye nokungacaphukisi. Indlela esebenza ngayo i-metabolic emzimbeni icacile kwaye ayiphazamisi. Xa idibene namava eminyaka emininzi okusetyenziswa kweklinikhi, kunokucingelwa ukuba kwiidosi zemveli zamayeza, ukhuseleko lwayo luphezulu kakhulu, nto leyo eyenza ukuba ibe lukhetho oluthembekileyo lwe-excipient kwicandelo lamayeza.

Kufuneka kuqatshelwe ukuba ukhuseleko lwezinto ezincedisayo kufuneka luvavanywe ngokupheleleyo kunye nefomyula iyonke yolungiselelo oluthile (njengezinye izinto ezincedisayo, izithako ezisebenzayo zechiza). Ukhuseleko lonyango olunye alumeli ukhuseleko olupheleleyo lonyango. Ekugqibeleni, ukusetyenziswa kufuneka kulandele imiyalelo ekwileyibhile yechiza.

Kuzo zonke,I-PVP K25yipolymer enobunzima obuphakathi obuphantsi bemolekyuli eneempawu zokuncamathelisa eziguquguqukayo kunye nokwenza ifilimu. Idlala indima ebalulekileyo kumayeza, izinto zokuthambisa, kunye nokusetyenziswa kwemizi-mveliso, ngakumbi njengesihlanganisi, isinyibilikisi, kunye nesisasazi kwiinkqubo zokwenza, nto leyo eyenza ukuba ibe yinto encedisayo ebalulekileyo kwiimveliso zabathengi kunye nezemizi-mveliso.