iindaba

IHydroxypropyl beta-cyclodextrin, eyaziwa nangokuthi (i-2-hydroxypropyl) -β-cyclodextrin, i-athomu ye-hydrogen kwi-2-, i-3-, kunye ne-6-hydroxyl amaqela e-glucose eseleyo kwi-β-cyclodextrin (β-CD) ethatyathelwa indawo yi-hydroxypropyl kwi-hydroxypropoxy. I-HP-β-CD ayinayo kuphela impembelelo yemvulophu egqwesileyo kwiikhompawundi ezininzi ezifana ne-β-CD, kodwa ineenzuzo zokunyibilika kwamanzi aphezulu kunye nokuphucula izinga lokukhululwa kunye ne-bioavailability yamachiza afakwe kwi-vivo. Ukongeza, i-HP-β-CD lichiza eliye lafumana idatha yokhuseleko olubanzi oluqokelelweyo kwaye akukho ziphumo bezingalindelekanga. I-HP-β-CD isenokusetyenziswa njengesikhuseli seprotheni kunye nokuzinzisa.

I-Hydroxypropyl beta-cyclodextrin imhlophe okanye i-amorphous emhlophe okanye i-crystalline powder; Ayinavumba, imnandi kancinci; Ukungeniswa kobumanzi obunamandla. Le mveliso inyibilika ngokulula emanzini, i-soluble ngokulula kwi-methanol, i-ethanol, iphantse ingabikho kwi-acetone, i-trichloromethane.

Ukunyibilika kwei-hydroxypropyl -B-cyclodextrinemanzini kuhle kakhulu, kwaye i-degree substitution ye-4 nangaphezulu inokuxutywa namanzi kuyo nayiphi na imilinganiselo, kwaye inokuchithwa kwi-50% ye-ethanol kunye ne-methanol. Ine-hygroscopicity ethile. Kodwa umsebenzi onxulumene nomphezulu kunye nomsebenzi we-hemolytic uphantsi. Ayinakucaphuka kwizihlunu kwaye isisixhasi esifanelekileyo sokunyibilikisa kunye nesixhasi samayeza kwinaliti.

Isetyenziselwa ntoni iHydroxypropyl beta-cyclodextrin?

Kwintsimi yokutya kunye neziqholo

I-Hydroxypropyl beta-cyclodextrin inokuphucula ukuzinza kunye nokusebenza kwexesha elide leemolekyuli zondlo, ukugubungela okanye ukulungisa iphunga elibi kunye nencasa yeemolekyuli zokutya okunesondlo, kunye nokuphucula inkqubo yokuvelisa kunye nomgangatho wemveliso.

Kwizinto zokuthambisa

Izinto eziluhlaza zokuthambisa zingasetyenziswa njengezizinzisi, i-emulsifiers, i-deodorizers, njl., ezinokunciphisa ukukhuthazwa kwee-molecule ze-organic kwi-cosmetics kwi-skin kunye ne-mucous membrane tissues, ukuphucula ukuzinza kwezithako ezisebenzayo, kunye nokuthintela ukuguquguquka kunye ne-oxidation yezondlo. Inomlinganiselo othile we-hygroscopicity.

Kwintsimi yeyeza

IHydroxypropyl beta-cyclodextrininokuphucula ukunyibilika kwamanzi kwiziyobisi ezinganyibilikiyo, ukonyusa uzinzo kwiziyobisi, ukuphucula ukufumaneka kweziyobisi, ukwandisa ukusebenza kakuhle kwamalungiselelo eziyobisi okanye ukunciphisa umthamo, ukulungelelanisa okanye ukulawula isantya sokukhululwa kweziyobisi, kunye nokunciphisa ubutyhefu beziyobisi. Ingasetyenziselwa njengomphathi weziyobisi zomlomo, iinaliti, iinkqubo zokuhanjiswa kweziyobisi ze-mucosal (kubandakanya i-mucosa yeempumlo, i-rectum, i-cornea, njl.), iinkqubo ze-transdermal absorption zokuhanjiswa kweziyobisi, i-lipophilic targeted drug, kwaye ingasetyenziswa njengeprotheyini yomkhuseli kunye ne-stabilizer.