iindaba

IHydroxypropyl beta-cyclodextrin, eyaziwa nangokuthi (i-2-hydroxypropyl) -β-cyclodextrin, i-athomu ye-hydrogen kwi-2-, 3-, kunye ne-6-hydroxyl amaqela e-glucose eseleyo kwi-β-cyclodextrin (β-CD) ethatyathelwa indawo yi-hydroxypropyl ukuya. ihydroxypropoxy. I-HP-β-CD ayinayo kuphela impembelelo yemvulophu egqwesileyo kwiikhompawundi ezininzi ezifana ne-β-CD, kodwa ineenzuzo zokunyibilika kwamanzi aphezulu kunye nokuphucula izinga lokukhululwa kunye ne-bioavailability yamachiza afakwe kwi-vivo. Ukongeza, i-HP-β-CD lichiza eliye lafumana idatha yokhuseleko olubanzi oluqokelelweyo kwaye akukho ziphumo bezingalindelekanga. I-HP-β-CD isenokusetyenziswa njengesikhuseli seprotheni kunye nokuzinzisa.

I-Hydroxypropyl beta-cyclodextrin imhlophe okanye i-amorphous emhlophe okanye i-crystalline powder; Ayinavumba, imnandi kancinci; Ukungeniswa kobumanzi obunamandla. Le mveliso inyibilika ngokulula emanzini, i-soluble ngokulula kwi-methanol, i-ethanol, iphantse ingabikho kwi-acetone, i-trichloromethane.

Ukunyibilika kwei-hydroxypropyl -B-cyclodextrinemanzini kuhle kakhulu, kwaye i-degree substitution ye-4 nangaphezulu inokuxutywa namanzi kuyo nayiphi na imilinganiselo, kwaye inokuchithwa kwi-50% ye-ethanol kunye ne-methanol. Inomlinganiselo othile we-hygroscopicity. Kodwa umsebenzi onxulumene nomphezulu kunye nomsebenzi we-hemolytic uphantsi. Ayinakucaphuka kwizihlunu kwaye iyeyona nto ifanelekileyo yokuphucula isinyibilikisi kunye nesixhasi samayeza esitofwayo.

Isetyenziselwa ntoni iHydroxypropyl beta-cyclodextrin?

Kwintsimi yokutya kunye neziqholo

I-Hydroxypropyl beta-cyclodextrin inokuphucula ukuzinza kunye nokusebenza kwexesha elide leemolekyuli zondlo, ukugubungela okanye ukulungisa iphunga elibi kunye nencasa yeemolekyuli zokutya okunesondlo, kunye nokuphucula inkqubo yokuvelisa kunye nomgangatho wemveliso.

Kwizinto zokuthambisa

Izinto zokuthambisa zinokusetyenziswa njengezizinzisi, i-emulsifiers, i-deodorizers, njl.njl., ezinokunciphisa ukuvuselela iimolekyuli ze-organic kwizinto zokuthambisa eluswini nakwi-mucous membrane tissues, ziphucule uzinzo lwezithako ezisebenzayo, kwaye zithintele ukuvuthuluka kunye ne-oxidation yezondlo. . Inomlinganiselo othile we-hygroscopicity.

Kwintsimi yeyeza

IHydroxypropyl beta-cyclodextrininokuphucula ukunyibilika kwamanzi kwiziyobisi ezinganyibilikiyo, ukonyusa uzinzo kwiziyobisi, ukuphucula ukufumaneka kweziyobisi, ukwandisa ukusebenza kakuhle kwamalungiselelo eziyobisi okanye ukunciphisa umthamo, ukulungelelanisa okanye ukulawula isantya sokukhululwa kweziyobisi, kunye nokunciphisa ubutyhefu beziyobisi. Ingasetyenziselwa njengomphathi wamachiza omlomo, iinaliti, iinkqubo zokuhanjiswa kweziyobisi ze-mucosal (kubandakanya i-mucosa yeempumlo, i-rectum, i-cornea, njl. njl.), iinkqubo zokuhanjiswa kweziyobisi ze-transdermal, i-lipophilic ekujoliswe kuyo, kwaye inokusetyenziswa njengomkhuseli weprotheyini kunye ukuzinzisa.