iindaba

I-Hydroxypropyl beta-cyclodextrin, ekwaziwa ngokuba yi-(2-hydroxypropyl) -β-cyclodextrin, yi-atom ye-hydrogen kwiqela le-2-, 3-, kunye ne-6-hydroxyl yeentsalela zeglucose kwi-β-cyclodextrin (β-CD) ethathelwa indawo yi-hydroxypropyl ibe yi-hydroxypropoxy. I-HP-β-CD ayinayo nje kuphela impembelelo entle kwiikhompawundi ezininzi ezifana ne-β-CD, kodwa ikwanazo neenzuzo zokunyibilika kwamanzi amaninzi kunye nokuphucula izinga lokukhululwa kunye nokufumaneka kwezinto eziphilayo kwamayeza afakwe ngaphakathi emzimbeni. Ukongeza, i-HP-β-CD sisixa seziyobisi esinedatha yokhuseleko ebanzi eqokelelweyo kwaye akukho miphumo mibi. I-HP-β-CD ingasetyenziswa njengesikhuseli seprotheni kunye nesiqinisi.

I-Hydroxypropyl beta-cyclodextrin yi-powder emhlophe okanye emhlophe e-amorphous okanye e-crystalline; Ayinavumba, imnandi kancinci; I-induction enamandla yokufuma. Le mveliso inyibilika lula emanzini, inyibilika lula kwi-methanol, i-ethanol, ayinyibiliki phantse kwi-acetone, i-trichloromethane.

Ukunyibilika kwei-hydroxypropyl-B-cyclodextrinemanzini ilungile kakhulu, kwaye inqanaba lokutshintshwa kwe-4 nangaphezulu linokuxubana namanzi nangayiphi na indlela, kwaye linokunyibilikiswa kwi-ethanol engama-50% kunye ne-methanol. Ine-hygroscopicity ethile. Kodwa umsebenzi womphezulu ohambelanayo kunye nomsebenzi we-hemolytic uphantsi kakhulu. Ayinazo izihlunu ezirhabaxa kwaye sisixhobo esifanelekileyo sokuphucula i-solvent kunye ne-pharmaceutical excipient sokujova.

Isetyenziselwa ntoni iHydroxypropyl beta-cyclodextrin?

Kwintsimi yokutya neziqholo

I-Hydroxypropyl beta-cyclodextrin inokuphucula uzinzo kunye nokusebenza kwexesha elide kweemolekyuli zesondlo, igqume okanye ilungise ivumba elibi kunye nencasa yeemolekyuli zesondlo sokutya, kwaye iphucule inkqubo yemveliso kunye nomgangatho wemveliso.

Kwizinto zokuthambisa

Izinto ezisetyenziswa kwizinto zokuthambisa zingasetyenziswa njengeziqinisi, izixubisisi, izixubisisi, njl.njl., ezinokunciphisa ukukhuthazwa kweemolekyuli zezinto eziphilayo kwizinto zokuthambisa eluswini nakwizicubu ze-mucous membrane, ziphucule uzinzo lwezithako ezisebenzayo, kwaye zithintele ukuguquguquka kunye nokuxinana kwezondlo. Inendawo ethile ehambelanayo ne-hygroscopicity.

Kwicandelo lezonyango

I-Hydroxypropyl beta-cyclodextrininokuphucula ukunyibilika kwamanzi kwamayeza anganyibilikiyo, yonyuse uzinzo lwamayeza, iphucule ukufumaneka kwamayeza, yonyuse ukusebenza kakuhle kwamalungiselelo amayeza okanye inciphise umthamo, ilungise okanye ilawule isantya sokukhululwa kwamayeza, kwaye inciphise ubuthi bamayeza. Ingasetyenziswa njengomthwali wamayeza athethwayo, iinaliti, iinkqubo zokuhambisa amayeza e-mucosal (kubandakanya i-mucosa yempumlo, i-rectum, i-cornea, njl.njl.), iinkqubo zokuhambisa amayeza e-transdermal absorption, amayeza ajoliswe kwi-lipophilic, kwaye ingasetyenziswa njengomkhuseli kunye nokuzinzisa iiproteni.