iindaba

Ukuze ulusu lunyamekeke kakuhle, ewe, akunakuphepheka ukuba nombono othile ngezithako, kungekuphela nje ukukhuthazwa kwemveliso, kodwa kunye nezithako zemveliso. Namhlanje, masithethe nge "carnosine" yezithako zeemveliso zokhathalelo lolusu.

Yintoni 'iCarnosine'
I-Carnosine yi-dipeptide eyenziwe yi-beta-alanine kunye ne-L-histidine, enomxholo ophezulu kwimisipha nakwizithintelo zobuchopho. I-Carnosine ineempawu eziphezulu ze-antioxidant kwaye inokususa ii-free radicals emzimbeni.

Indlela esebenza ngayo 'i-carnosine'
I-Carnosine inokunyusa ukumelana nolusu, igcine imeko yobutsha beeseli ngokugcina umsebenzi weeseli kwi-full spectrum band kunye neemeko ze-free radicals, ikhuthaze ukuveliswa kwe-collagen, kwaye igcine ulusu luthambile.

Indima 'ye-carnosine'
I-Carnosine inokunyusa ukumelana nolusu, igcine imeko yobutsha beeseli ngokugcina umsebenzi weeseli kwi-full spectrum band kunye neemeko ze-free radicals, ikhuthaze ukuveliswa kwe-collagen, kwaye igcine ulusu luthambile. Uhlobo lweekhemikhali ze-I-L-carnosinekukwenziwa kwe-beta-alanine kunye ne-L-histidine ngesenzo se-carnosine synthase. I-Carnosine inamathuba amaninzi okusetyenziswa kwicandelo lezonyango, ukhathalelo lwempilo, kunye nococeko ngenxa yeempawu zayo ze-antioxidant, iziphumo zokususa ii-radicals zasimahla, i-chelation ene-transition metals, ukhuseleko lwe-neuro, ukukhuthaza ukuphiliswa kwamanxeba, kunye nokulwa nokwaluphala.

1. Ukusetyenziswa kwe-carnosine kwishishini lokutya
Eyona nto iphambili kwioyile ekutyeni ngumxube wee-glycerides ezahlukeneyo ze-fatty acid. Ngenxa ye-free radical reaction ye-unsaturated fatty acid glycerides ngexesha lokugcinwa, ii-peroxides kunye ne-odorous aldehydes okanye ii-carboxylic acids ezinee-short carbon chains ziyaveliswa. Ke ngoko, ukutya ukutya okuqulethe ii-fat peroxides kuya kukhuthaza ngakumbi i-lipid peroxidation emizimbeni yabantu kwaye kubangele izifo ezahlukeneyo. Ke ngoko, i-butylated hydroxyanisole, i-dibutylated hydroxytoluene, i-propyl gallate, njl. zihlala zisetyenziswa ekulungisweni nasekugcinweni kokutya ukuthintela i-fat peroxidation, kodwa ukusebenza kwazo kuya kuncipha kwinkqubo yokufudumeza yokulungiswa kokutya, kwaye inetyhefu ethile. I-L-carnosine ayinakuthintela kuphela i-fat oxidation ngokufanelekileyo, kodwa ikwanemisebenzi ephezulu yokhuseleko kunye nokhathalelo lwempilo. Ke ngoko, i-L-carnosine yi-antioxidant yokutya exabisekileyo nefanelekileyo.
2. Ukusetyenziswa kwe-carnosine kunyango nakwinkathalelo yempilo
(1) I-Carnosine kunye ne-Antioxidant

I-Carnosine ayinakusebenzisa kuphela i-imidazole ring N atom kunye ne-peptide bond N atom kwi-histidine residues ukuze i-chelate metal ions kwaye ithintele i-fat oxidation ebangelwa yi-metal ions, kodwa ne-histidine kwi-side chain ye-carnosine inako ukubamba ii-hydroxyl radicals. Inokuthintela i-oxidation yamafutha ebangelwa yi-non-metal ions. Ke ngoko, njengesixhobo esisebenzayo se-antioxidant esisebenzayo, i-carnosine inokukhusela ngokuzinzileyo i-cell membrane kwaye yi-free radical scavenger enyibilikayo emanzini. , inokuthintela i-peroxidation ye-cell membrane. Xa ithelekiswa nezinye ii-antioxidants zebhayoloji ezifana ne-VC, i-carnosine inomthamo onamandla we-antioxidant. Ukongeza ekuthinteleni inkqubo ye-peroxidation ye-cell membrane, i-carnosine inokuthintela uthotho lwezinye iimpendulo ze-intracellular peroxidation, oko kukuthi, i-carnosine inokuthintela inyathelo ngalinye le-oxidation reaction kuyo yonke i-peroxidation chain kwi-organism. Indima yee-antioxidants ezifana ne-VC kukuthintela ii-free radicals ukuba zingangeni kwizicubu, oko kukuthi, zinokuthintela kuphela inkqubo ye-liquid peroxidation ye-membrane yeseli, kwaye azinakwenza nto kwii-free radicals ezingene kwiseli.
(2) I-Carnosine kunye nesilonda esiswini

Isilonda sePeptic sisifo senkqubo yokugaya ukutya esingapheliyo esixhaphakileyo kwihlabathi liphela, kwaye izinto ezithile ezibangela izilonda azicaci kakuhle okwangoku, kodwa i-pathology ikholelwa ukuba izinto ezinobundlongondlongo (ezifana ne-asidi yesisu, ukukhutshwa kwe-pepsin, usulelo lwe-Helicobacter pylori) kunye nokuthintela okanye iiseli. Oku kubangelwa kukungalingani kwezinto ezikhuselayo (ukukhutshwa kwe-mucus, ukukhutshwa kwe-bicarbonate, ukuveliswa kwe-prostaglandin). Indlela yendalo yokukhusela isisu yile: yenza umaleko omkhulu we-mucosa yesisu osebenza njengomqobo wokuzikhusela ukukhusela iiseli ezikwi-lining. Ukukhutshwa okuqhubekayo kwe-mucous membrane kukhusela isisu, kodwa ukukhutshwa okugqithisileyo kunokubangela izilonda zesisu. Izifundo zifumanise ukuba i-zinc-carnosine ethathwe kunye nokutya inokuthintela izilonda ngempumelelo, inokugcina ngokufanelekileyo ukuthembeka kwesisu kunye nendlela yayo yendalo yokukhusela, oku kungenxa yeempawu ze-antioxidant ze-carnosine, ukuzinza kwe-membrane, ummiselo Iipropati ze-pharmacological ze-immune kunye nokulungisa izicubu. Ngokwezilingo zeklinikhi, emva kokuthatha i-zinc-carnosine iiveki ezisibhozo, ama-70% ezigulana ezithathe eli yeza zibonise ukuphucuka okukhulu, kwaye ama-65% ezilonda zesisu aphuculwe nge-gastoscopy.
(3) Ukulawulwa kwe-carnosine kunye nomzimba

Impendulo yomzimba ngumsebenzi we-physiological ogcina i-homeostasis kwaye ulawulwa zizinto ezisebenzayo emzimbeni kwizinto eziphilayo. Ii-immunomodulators zibhekisa kunyango lweentlobo zezifo ezibangelwa kukungasebenzi kakuhle komzimba, kwaye zisetyenziselwa ukubuyisela impendulo yomzimba, ukuthintela ukwehla kwayo okungaqhelekanga okanye ukuthintela impendulo yayo ngokukhawuleza. Uninzi lwee-immunomodulators ezikhoyo zenziwe ngeendlela zokwenziwa kweekhemikhali, ezineempembelelo ezithile ezinobungozi kunye neziphumo ebezingalindelekanga. Izifundo zibonise ukuba i-carnosine inomsebenzi we-immunomodulatory, kwaye yeyona nto kuphela esebenzayo emzimbeni efunyenweyo ukuza kuthi ga ngoku kwi-immunomodulation, kwaye isetyenzisiwe kakhulu kunyango lwezifo ezahlukeneyo zomzimba kunye nezifo ezibangelwa kukungasebenzi kakuhle komzimba.