iindaba

Ukunyamekela ulusu olusebenzayo, ngokuqinisekileyo, akunakuphepheka ukuba nombono othile wezithako, kungekhona nje ukukhuthazwa kwemveliso, kodwa kunye nezithako zemveliso. Namhlanje, makhe sithethe "nge-carnosine" yezithako zeemveliso zokunakekelwa kwesikhumba.

Yintoni 'iCarnosine'
I-Carnosine yidipeptide eyenziwe yi-beta-alanine kunye ne-L-histidine, enomxholo ophezulu kwimisipha kunye neebhloko zengqondo. I-Carnosine ineepropathi eziphezulu ze-antioxidant kwaye inokukhupha ii-radicals zamahhala emzimbeni.

Isebenza njani 'i-carnosine'
I-Carnosine inokonyusa ukuchasana kolusu, igcine imeko yolutsha lweeseli ngokugcina umsebenzi weeseli kwibhendi ye-spectrum epheleleyo kunye neemeko ze-radical zasimahla, ukukhuthaza ukuveliswa kwe-collagen, kunye nokugcina ulusu lunwebeka.

Indima 'ye-carnosine'
I-Carnosine inokonyusa ukuchasana kolusu, igcine imeko yolutsha lweeseli ngokugcina umsebenzi weeseli kwibhendi ye-spectrum epheleleyo kunye neemeko ze-radical zasimahla, ukukhuthaza ukuveliswa kwe-collagen, kunye nokugcina ulusu lunwebeka. Ubume bekhemikhali yeL-carnosinekukubunjwa kwe-beta-alanine kunye ne-L-histidine ngokusebenzisa isenzo se-carnosine synthase. I-Carnosine inethemba elibanzi lesicelo kwiinkalo zonyango, ukhathalelo lwempilo, kunye nococeko ngenxa yeempawu zayo zokulwa ne-antioxidant, i-free radical scavenging effects, i-chelation nge-transition metals, neuroprotection, ukukhuthaza ukuphiliswa kwenxeba, kunye nokuchasana nokuguga.

1. Ukusetyenziswa kwe-carnosine kwishishini lokutya
Inxalenye ephambili yeoli ekutyeni ngumxube we-fatty acid glycerides eyahlukeneyo. Ngenxa yokusabela kwe-radical yamahhala ye-unsaturated fatty acid glycerides ngexesha lokugcinwa, i-peroxides kunye ne-aldehydes enevumba elimnandi okanye i-carboxylic acids kunye neentambo zekhabhoni ezimfutshane zenziwe. Ke ngoko, ukutya ukutya okuneeperoxides ezinamafutha kuya kukhuthaza ngakumbi i-lipid peroxidation emizimbeni yabantu kwaye kubangele izifo ezahlukeneyo. Ngoko ke, i-hydroxyanisole ye-butylated, i-dibutylated hydroxytoluene, i-propyl gallate, njl. I-L-carnosine ayikwazi ukuthintela ngokufanelekileyo i-oxidation yamafutha, kodwa inokhuseleko oluphezulu kunye nemisebenzi yokunakekelwa kwempilo. Ngoko ke, i-L-carnosine yinto exabisekileyo kwaye ifanelekileyo yokutya i-antioxidant.
2. Ukusetyenziswa kwe-carnosine kumayeza kunye nokhathalelo lwempilo
(1) I-Carnosine kunye ne-Antioxidant

I-Carnosine ayikwazi ukusebenzisa kuphela i-imidazole ring N athom kunye ne-peptide bond N kwi-athom ye-histidine ukuze i-chelate i-ion yensimbi kwaye inqanda i-oxidation yamanqatha ebangelwa yi-ion yensimbi, kodwa kwakhona i-histidine esecaleni kwekhonkco le-carnosine inamandla okubamba i-hydroxyl radicals. Inokuthintela i-oxidation yamanqatha ebangelwa ii-ion ezingezizo zetsimbi. Ngoko ke, njengento esebenzayo ye-antioxidant esebenzayo, i-carnosine inokukhusela ngokuzinzileyo i-membrane yeseli kwaye i-soluble water-soluble free radical scavenger. , inokuthintela i-peroxidation ye-membrane yeseli. Xa kuthelekiswa namanye ama-antioxidants ebhayoloji afana ne-VC, i-carnosine inomthamo onamandla wokulwa ne-antioxidant. Ukongeza ekuvimbeleni inkqubo ye-peroxidation ye-membrane yeseli, i-carnosine inokuthintela uchungechunge lwezinye iimpendulo ze-intracellular peroxidation, oko kukuthi, i-carnosine inokuthintela yonke inyathelo le-oxidation reaction kulo lonke ikhonkco le-peroxidation emzimbeni. Indima ye-antioxidants efana ne-VC kukuthintela i-radicals yasimahla ukuba ingangeni kwithishu, oko kukuthi, inokuthintela kuphela inkqubo ye-peroxidation yolwelo lwe-membrane yeseli, kwaye ayinakwenza nto kwiiradicals zasimahla ezingene kwiseli.
(2) Carnosine kunye nesilonda esiswini

I-Peptic ulcer sisifo senkqubo yokugaya ukutya okungapheliyo, kwaye izinto ezithile ezibangela izilonda azikacaci kakuhle okwangoku, kodwa i-pathology ikholelwa ukuba izinto ezinobundlobongela (ezifana ne-gastric acid, i-pepsin secretion, i-Helicobacter pylori infection) kunye nothintelo okanye iselula ukungalingani kwezinto ezikhuselayo (i-mucus secretion, i-bicarbonate secretion, imveliso ye-prostaglandin). Indlela yokukhusela yendalo yesisu yile: yenza umaleko otyebileyo we-gastric mucosa esebenza njengesithintelo sokukhusela ukukhusela iiseli ezikwi-lining. Imfihlo eqhubekayo ye-membrane ye-mucous ikhusela isisu, kodwa ukukhutshwa ngokugqithiseleyo kunokubangela izilonda zesisu. Uphononongo lufumene ukuba i-zinc-carnosine ethathwe ngokutya inokuthintela ngokufanelekileyo izilonda, inokugcina ngokufanelekileyo ingqibelelo yesisu kunye nenkqubo yayo yokukhusela yendalo, oku kungenxa yeempawu ze-carnosine ze-antioxidant, ukuzinza kwe-membrane, ummiselo we-Pharmacological properties of immune and repair tissues. Ngokutsho kwezilingo zeklinikhi, emva kokuthatha i-zinc-carnosine kwiiveki ezisibhozo, i-70% yezigulane ezithatha ichiza zibonise ukuphucuka okukhulu, kwaye i-65% yezilonda zesisu zaphuculwa nge-gastroscopy.
(3) I-Carnosine kunye ne-immune regulation

Ukuphendula kwamajoni omzimba ngumsebenzi we-physiological ogcina i-homeostasis kwaye ilawulwa yizinto ezisebenzayo ze-physiologically kwizinto eziphilayo. I-Immunomodulators ibhekisela kunyango lweklasi yezifo ezibangelwa ukungasebenzi komzimba, kwaye zisetyenziselwa ukubuyisela impendulo yokuzivikela, inqanda ukuhla kwayo okungaqhelekanga okanye ukucinezela ukuphendula kwayo ngokukhawuleza. Uninzi lwama-immunomodulators asele lukhona ludityaniswe ngeendlela zokwenziwa kweekhemikhali, ezinetyhefu ethile kunye neziphumo ebezingalindelekanga. Uphononongo lubonise ukuba i-carnosine inomsebenzi we-immunomodulatory, kwaye yinto kuphela esebenzayo ye-physiologically efunyenweyo ukuza kuthi ga ngoku kwi-immunomodulation, kwaye isetyenziswe ngokubanzi kunyango lwezifo ezahlukeneyo zokuzivikela kunye nezifo ezibangelwa yi-immunity engaqhelekanga.