Metronidazole CAS 443-48-1

I-CAS:443-48-1

Ifomula yemolekyuli:C6H9N3O3

Ubunzima beMolekyuli:171.15

EINECS:207-136-1

Izithethantonye:I-TIMTEC-BB SBB001486; I-1-(2-Hydroxy-1-ethyl) -2-methyl-5-nitroimidazole; I-1-(2-hydroxyethyl) -2-methyl-5-nitroimidazole; I-1-(beta-Hydroxyethyl) -2-methyl-5-nitroimidazole; I-1-(beta-Oxyethyl) -2-methyl-5-nitroimidazole; I-1H-Imidazole-1-ethanol, i-2-methyl-5-nitro-; I-1H-Imidazole-1-ethanol, i-2-methyl-5-nitro-; I-1-Hydroxyethyl-2-methyl-5-nitroimidazole; I-2-(2-Methyl-5-nitro-1H-imidazol-1-yl) ithanol; I-2-Methyl-1- (2-hydroxyethyl) -5-nitroimidazole

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Khuphela

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Yintoni iMetronidazole CAS 443-48-1?

I-Metronidazole yikristale emhlophe okanye etyheli kancinane okanye icrystalline powder; Kukho ivumba elincinci, kunye nencasa ekrakra kunye netyuwa. Inyibilika kancinane kwi-ethanol, inyibilika kancinane emanzini okanye kwiklorofomu, kwaye inyibilika kancinane kakhulu kwi-ether. I-Metronidazole yi-nitrogen-equlethe i-heterocyclic ikhompawundi ene-alkalinity kunye nokunyibilika kwamanzi aphantsi. Ngokomgaqo weprodrug, i-metronidazole yenziwe kwi-potassium phosphate ester, eyandisa ukunyibilika kwayo emanzini kwaye inokusetyenziswa njengesisombululo sokutofa.

Inkcazo

Into	Inkcazo
Indawo yokubilisa	301.12°C (uqikelelo olurhabaxa)
Ukuxinana	1.3994 (uqikelelo olurhabaxa)
Indawo yokunyibilika	159-161 °C (isibane.)
pKa	pKa 2.62(H2O,t =25±0.2,
Iimeko zokugcina	2-8°C

Isicelo

I-Metronidazole inefuthe elinamandla lokulwa neebhaktheriya kwiibhaktheriya ezininzi ze-anaerobic kwaye isetyenziselwa ukunyanga i-amoebiasis, i-trichomoniasis, kunye nosulelo lwebhaktiriya ye-anaerobic. Ikwasetyenziselwa ukunyanga i-trichomoniasis ye-vaginal kwaye isetyenziswe kwi-amoebiasis yamathumbu kunye ne-extraintestinal ukususela ngo-1970. Ukusebenza kwayo kuphezulu, i-toxicity iphantsi, kwaye isetyenziswa kakhulu. Ineziphumo ze-mutagenic kunye ne-teratogenic kwiimvavanyo zezilwanyana.