I-Celastrol CAS 34157-83-0

Celastrol CAS 34157-83-0 Umfanekiso ofakiweyo

I-CAS:34157-83-0

Ifomula yemolekyuli:C29H38O4

Ubunzima beMolekyuli:450.61

EINECS:636-472-5

Izithethantonye:I-CELASTROL(SH); I-CELASTROL; Celastrol (Tripterin); I-CELASTROL(P)(NCEDA UFOWELE); (20R) -3-Hydroxy-2-oxo-24-nor-D: A-friedoolean-1 (10), 3,5,7-tetren-29-oic acid; I-2-Oxo-3-hydroxy-24-norfriedela-1 (10), 3,5,7-tetraene-29-oic acid; I-2-Oxo-3-hydroxy-24-norfriedelane-1 (10), 3,5,7-tetraene-29-oic acidI-Celasterol

Shiya uMyalezo Wakho

Iinkcukacha zeMveliso

Khuphela

Iithegi zeMveliso

Yintoni i-Celastrol CAS 34157-83-0?

I-Celastrol ayinyibiliki emanzini, i-soluble kwi-dimethyl sulfoxide kunye ne-anhydrous ethanol. Ithathwe kwizithako ezichasene nomhlaza ezisebenzayo kwizityalo ezifana neThunder God Vine kunye neSouth Snake Vine kwintsapho yeCelastraceae. Iproteasome inhibitor esebenzayo, eqinisekisiweyo ukuba ibangele i-apoptosis yeseli yomhlaza ngokuthintela umsebenzi weproteasome.

Inkcazo

Into	Inkcazo
Indawo yokubilisa	645.7±55.0 °C(Kuxelwe kwangaphambili)
Ukuxinana	1.2
Indawo yokunyibilika	219-230°C
pKa	4.78±0.70(Kuqikelelwe)
λmax	424nm(MeOH)(lit.)
Iimeko zokugcina	-20°C

Isicelo

I-Celastrol isetyenziselwa ukuzimisela komxholo / ukuchongwa / iimvavanyo ze-pharmacological, njl. Iziphumo ze-Pharmacological: Inezixhobo ezinamandla ze-antioxidant, i-anti-cancer angiogenesis effects, kunye ne-anti-rheumatoid effects. Iproteasome inhibitor esebenzayo, eqinisekisiweyo ukuba ibangele i-apoptosis yeseli yomhlaza ngokuthintela umsebenzi weproteasome.